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Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice

Overview of attention for article published in BMC Complementary Medicine and Therapies, September 2017
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Title
Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice
Published in
BMC Complementary Medicine and Therapies, September 2017
DOI 10.1186/s12906-017-1955-1
Pubmed ID
Authors

Yun Mi Lee, Eun-Jung Shon, Ohn Soon Kim, Dong-Seon Kim

Abstract

Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-induced gouty arthritis in a mouse model. An MSU crystal suspension (4 mg/50 μL) was injected intradermally into the right paw. The mice were orally administered MPE (150 mg/kg or 300 mg/kg) or the positive control drug colchicine (1 mg/kg) 1 h before the MSU crystals were injected and then once daily for 3 days. The effects of MPE included inflammatory paw edema and pain upon weight-bearing activity, and we evaluated the inflammatory cytokine expression and paw tissue inflammation-related gene expression. MPE suppressed inflammatory paw edema and pain in the MSU-induced mice. MPE showed anti-inflammatory activity by inhibiting the production of TNF-α, interleukin (IL)-1β, NLRP3 inflammasome and NF-κB. These results suggest that MPE has potent anti-inflammatory activities and may be useful as a therapeutic agent against gouty arthritis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 18%
Student > Master 4 12%
Other 2 6%
Student > Bachelor 2 6%
Unspecified 2 6%
Other 6 18%
Unknown 11 33%
Readers by discipline Count As %
Medicine and Dentistry 6 18%
Pharmacology, Toxicology and Pharmaceutical Science 4 12%
Nursing and Health Professions 3 9%
Unspecified 2 6%
Immunology and Microbiology 2 6%
Other 4 12%
Unknown 12 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2017.
All research outputs
#20,446,373
of 23,001,641 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,988
of 3,641 outputs
Outputs of similar age
#275,643
of 315,600 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#75
of 99 outputs
Altmetric has tracked 23,001,641 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,641 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,600 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.