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Neurogenetic plasticity and sex influence the link between corticolimbic structural connectivity and trait anxiety

Overview of attention for article published in Scientific Reports, September 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

twitter
10 tweeters

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
19 Mendeley
Title
Neurogenetic plasticity and sex influence the link between corticolimbic structural connectivity and trait anxiety
Published in
Scientific Reports, September 2017
DOI 10.1038/s41598-017-11497-2
Pubmed ID
Authors

M. Justin Kim, Reut Avinun, Annchen R. Knodt, Spenser R. Radtke, Ahmad R. Hariri

Abstract

Corticolimbic pathways connecting the amygdala and ventral prefrontal cortex (vPFC) are linked with trait anxiety, but it remains unclear what potential genetic moderators contribute to this association. We sought to address this by examining the inter-individual variability in neuroplasticity as modeled by a functional polymorphism (rs6265) in the human gene for brain derived neurotrophic factor (BDNF). Amygdala-vPFC pathway fractional anisotropy (FA) from 669 diffusion magnetic resonance images was used to examine associations with trait anxiety as a function of rs6265 genotype. We first replicated the inverse correlation between trait anxiety and amygdala-vPFC pathway FA in women. Furthermore, we found a moderating influence of rs6265 genotype such that the association between trait anxiety and right amygdala-vPFC pathway FA was strongest in women carrying the Met allele, which is linked with decreased activity-dependent neuroplasticity. Results indicate that the microstructural integrity of pathways supporting communication between the amygdala and vPFC help shape the expression of trait anxiety in women, and that this association is further modulated by genetically driven variability in neuroplasticity.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Student > Bachelor 3 16%
Student > Master 2 11%
Unspecified 2 11%
Student > Postgraduate 2 11%
Other 5 26%
Readers by discipline Count As %
Unspecified 5 26%
Psychology 5 26%
Neuroscience 5 26%
Agricultural and Biological Sciences 2 11%
Social Sciences 1 5%
Other 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2017.
All research outputs
#2,824,986
of 11,771,256 outputs
Outputs from Scientific Reports
#15,879
of 51,825 outputs
Outputs of similar age
#77,150
of 264,505 outputs
Outputs of similar age from Scientific Reports
#1,332
of 4,094 outputs
Altmetric has tracked 11,771,256 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,825 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 4,094 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.