Title |
Towards a comprehensive Plasmodium falciparum merozoite cell surface and secreted recombinant protein library
|
---|---|
Published in |
Malaria Journal, March 2014
|
DOI | 10.1186/1475-2875-13-93 |
Pubmed ID | |
Authors |
Zenon A Zenonos, Julian C Rayner, Gavin J Wright |
Abstract |
Plasmodium falciparum is the aetiological agent for malaria, a deadly infectious disease for which no vaccine has yet been licensed. The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form. To address this, a method that enables the systematic expression of functional extracellular Plasmodium proteins was previously developed, and used to create a library of 42 merozoite proteins. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Kenya | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 33% |
Student > Master | 13 | 20% |
Researcher | 12 | 19% |
Student > Bachelor | 5 | 8% |
Student > Postgraduate | 3 | 5% |
Other | 6 | 9% |
Unknown | 4 | 6% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 29 | 45% |
Biochemistry, Genetics and Molecular Biology | 16 | 25% |
Immunology and Microbiology | 5 | 8% |
Chemistry | 3 | 5% |
Medicine and Dentistry | 3 | 5% |
Other | 3 | 5% |
Unknown | 5 | 8% |