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Sequencing-based approach identified three new susceptibility loci for psoriasis.

Overview of attention for article published in Nature Communications, January 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

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3 tweeters

Citations

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33 Dimensions

Readers on

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9 Mendeley
Title
Sequencing-based approach identified three new susceptibility loci for psoriasis.
Published in
Nature Communications, January 2014
DOI 10.1038/ncomms5331
Pubmed ID
Authors

Yujun Sheng, Xin Jin, Jinhua Xu, Jinping Gao, Xiaoqing Du, Dawei Duan, Bing Li, Jinhua Zhao, Wenying Zhan, Huayang Tang, Xianfa Tang, Yang Li, Hui Cheng, Xianbo Zuo, Junpu Mei, Fusheng Zhou, Bo Liang, Gang Chen, Changbing Shen, Hongzhou Cui, Xiaoguang Zhang, Change Zhang, Wenjun Wang, Xiaodong Zheng, Xing Fan, Zaixing Wang, Fengli Xiao, Yong Cui, Yingrui Li, Jun Wang, Sen Yang, Lei Xu, Liangdan Sun, Xuejun Zhang

Abstract

In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 33%
Student > Ph. D. Student 3 33%
Researcher 2 22%
Student > Bachelor 1 11%
Readers by discipline Count As %
Unspecified 3 33%
Medicine and Dentistry 2 22%
Biochemistry, Genetics and Molecular Biology 1 11%
Psychology 1 11%
Neuroscience 1 11%
Other 1 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#2,624,984
of 6,577,121 outputs
Outputs from Nature Communications
#7,469
of 10,065 outputs
Outputs of similar age
#58,178
of 149,873 outputs
Outputs of similar age from Nature Communications
#417
of 556 outputs
Altmetric has tracked 6,577,121 research outputs across all sources so far. This one has received more attention than most of these and is in the 59th percentile.
So far Altmetric has tracked 10,065 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.5. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 556 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.