Sequencing-based approach identified three new susceptibility loci for psoriasis.
Nature Communications, January 2014
Yujun Sheng, Xin Jin, Jinhua Xu, Jinping Gao, Xiaoqing Du, Dawei Duan, Bing Li, Jinhua Zhao, Wenying Zhan, Huayang Tang, Xianfa Tang, Yang Li, Hui Cheng, Xianbo Zuo, Junpu Mei, Fusheng Zhou, Bo Liang, Gang Chen, Changbing Shen, Hongzhou Cui, Xiaoguang Zhang, Change Zhang, Wenjun Wang, Xiaodong Zheng, Xing Fan, Zaixing Wang, Fengli Xiao, Yong Cui, Yingrui Li, Jun Wang, Sen Yang, Lei Xu, Liangdan Sun, Xuejun Zhang
In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.
|Members of the public||2||67%|
|Readers by professional status||Count||As %|
|Student > Ph. D. Student||3||33%|
|Student > Bachelor||1||11%|
|Readers by discipline||Count||As %|
|Medicine and Dentistry||2||22%|
|Biochemistry, Genetics and Molecular Biology||1||11%|