Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.

Overview of attention for article published in Virology, July 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 1,511)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
8 news outlets
twitter
1 tweeter

Readers on

mendeley
21 Mendeley
Title
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Published in
Virology, July 2014
DOI 10.1016/j.virol.2014.06.019
Pubmed ID
Authors

Wolf AI, Strauman MC, Mozdzanowska K, Williams KL, Osborne LC, Shen H, Liu Q, Garlick D, Artis D, Hensley SE, Caton AJ, Weiser JN, Erikson J

Abstract

The response to influenza virus (IAV) infection and severity of disease is highly variable in humans. We hypothesized that one factor contributing to this variability is the presence of specific respiratory tract (RT) microbes. One such microbe is Streptococcus pneumoniae (Sp) that is carried asymptomatically in the RT of many humans. In a mouse co-infection model we found that in contrast to secondary bacterial infection that exacerbates disease, Sp colonization 10 days prior to IAV protects from virus-induced morbidity and lung pathology. Using mutant Sp strains, we identified a critical role for the bacterial virulence factor pneumolysin (PLY) in mediating this protection. Colonization with the PLY-sufficient Sp strain induces expression of the immune-suppressive enzyme arginase 1 in alveolar macrophages (aMø) and correlates with attenuated recruitment and function of pulmonary inflammatory cells. Our study demonstrates a novel role for PLY in Sp-mediated protection by maintaining aMø as "gatekeepers" against virus-induced immunopathology.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 2 10%
Switzerland 1 5%
United Kingdom 1 5%
United States 1 5%
Unknown 16 76%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 29%
Student > Bachelor 5 24%
Student > Master 2 10%
Researcher 2 10%
Lecturer > Senior Lecturer 2 10%
Other 4 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 76%
Medicine and Dentistry 4 19%
Social Sciences 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score was calculated when the research output was last mentioned on 11 July 2014.
All research outputs
#49,917
of 4,229,096 outputs
Outputs from Virology
#5
of 1,511 outputs
Outputs of similar age
#2,778
of 103,551 outputs
Outputs of similar age from Virology
#1
of 58 outputs
Altmetric has tracked 4,229,096 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,511 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,551 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.