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Early and late Iron supplementation for low birth weight infants: a meta-analysis

Overview of attention for article published in Italian Journal of Pediatrics, March 2015
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Title
Early and late Iron supplementation for low birth weight infants: a meta-analysis
Published in
Italian Journal of Pediatrics, March 2015
DOI 10.1186/s13052-015-0121-y
Pubmed ID
Authors

Hong-Xing Jin, Rong-Shan Wang, Shu-Jun Chen, Ai-Ping Wang, Xi-Yong Liu

Abstract

Iron deficiency in infancy is associated with a range of clinical and developmentally important issues. Currently, it is unclear what is the optimal timing to administer prophylactic enteral iron supplementation in preterm and very low birth weight infants. The objective of this meta-analysis was to evaluate early compared with late iron supplementation in low birth weight infants. PubMed and Cochrane Library databases were searched up to May 10, 2014 for studies that compared the benefit of early and late iron supplementation in infants of low birth weight. Sensitivity analysis was carried out using the leave one-out approach and the quality of the included data was assessed. The data base search and detailed review identified four studies that were included in the meta-analysis. The number of included patients was 246 (n = 121 for early supplementation and n = 125 for late supplementation) and the majority were premature infants. Across studies, early supplementation ranged from as early as enteral feeding was tolerated to 3 weeks, and late supplementation ranged from 4 weeks to about 60 days. Early treatment was associated with significantly smaller decreases in serum ferritin and hemoglobin levels (P < 0.001). In addition, the rate of blood transfusions was lower with early compared with late iron supplementation (P = 0.022). There was no difference between early and late supplementation in the number of patients with nectorizing enteroclitis (>bell stage 2) (P = 0.646). Sensitivity analysis indicated no one study overly influenced the findings and that the data was reliable. In conclusion, early iron supplementation resulted in less a decrease in serum ferritin and hemoglobin levels in infants with low birth rate. However, caution should be used when treating infants with iron so as not to result in iron overload and possibly negative long-term effects on neurodevelopment.

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Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 139 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 19%
Student > Bachelor 19 14%
Other 14 10%
Researcher 12 9%
Student > Postgraduate 11 8%
Other 27 19%
Unknown 30 21%
Readers by discipline Count As %
Medicine and Dentistry 72 51%
Nursing and Health Professions 13 9%
Agricultural and Biological Sciences 7 5%
Biochemistry, Genetics and Molecular Biology 3 2%
Economics, Econometrics and Finance 2 1%
Other 8 6%
Unknown 35 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2017.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Italian Journal of Pediatrics
#739
of 1,059 outputs
Outputs of similar age
#205,915
of 277,672 outputs
Outputs of similar age from Italian Journal of Pediatrics
#14
of 17 outputs
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.