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Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I)

Overview of attention for article published in Veterinary Research, August 2011
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  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 1,339)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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46 X users
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1 Wikipedia page

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49 Dimensions

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58 Mendeley
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Title
Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I)
Published in
Veterinary Research, August 2011
DOI 10.1186/1297-9716-42-97
Pubmed ID
Authors

Fabian Deutskens, Benjamin Lamp, Christiane M Riedel, Eveline Wentz, Günter Lochnit, Klaus Doll, Heinz-Jürgen Thiel, Till Rümenapf

Abstract

A mysterious disease affecting calves, named bovine neonatal pancytopenia (BNP), emerged in 2007 in several European countries. Epidemiological studies revealed a connection between BNP and vaccination with an inactivated vaccine against bovine virus diarrhea (BVD). Alloantibodies reacting with blood leukocytes of calves were detected in serum and colostrum of dams, which have given birth to calves affected by BNP. To understand the linkage between vaccination and the development of alloantibodies, we determined the antigens reacting with these alloantibodies. Immunoprecipitation of surface proteins from bovine leukocytes and kidney cells using sera from dams with a confirmed case of BNP in their gestation history reacted with two dominant protein species of 44 and 12 kDa. These proteins were not detected by sera from dams, free of BVDV and not vaccinated against BVD, and from sera of animals vaccinated with a different inactivated BVD vaccine. The 44 kDa protein was identified by mass spectrometry analysis as MHC I, the other as β-2-microglobulin. The presence of major histocompatibility complex class I (MHC I) in the vaccine was confirmed by Western blot using a MHC I specific monoclonal antibody. A model of BNP pathogenesis is proposed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 3%
Denmark 1 2%
United States 1 2%
Unknown 54 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 16%
Researcher 8 14%
Other 6 10%
Student > Doctoral Student 6 10%
Student > Ph. D. Student 6 10%
Other 14 24%
Unknown 9 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 41%
Veterinary Science and Veterinary Medicine 11 19%
Medicine and Dentistry 7 12%
Business, Management and Accounting 1 2%
Nursing and Health Professions 1 2%
Other 4 7%
Unknown 10 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2023.
All research outputs
#1,102,358
of 25,405,598 outputs
Outputs from Veterinary Research
#24
of 1,339 outputs
Outputs of similar age
#4,587
of 135,519 outputs
Outputs of similar age from Veterinary Research
#2
of 12 outputs
Altmetric has tracked 25,405,598 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,339 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 135,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.