| Chapter title |
Developmental Neurotoxicity of Lead
|
|---|---|
| Chapter number | 1 |
| Book title |
Neurotoxicity of Metals
|
| Published in |
Advances in neurobiology, September 2017
|
| DOI | 10.1007/978-3-319-60189-2_1 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-960188-5, 978-3-31-960189-2
|
| Authors |
Caito, Samuel, Aschner, Michael, Samuel Caito, Michael Aschner |
| Abstract |
Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit hyperactivity disorder. In this review, we will discuss sources of developmental lead exposure and mechanisms of lead neurotoxicity. We will highlight both human epidemiological studies showing associations between lead exposure and behavioral abnormalities as well as experimental data from animal studies. Finally, we will discuss the effects of lead on neurological endpoint past childhood, namely, development of Alzheimer's disease in old age. |
X Demographics
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|---|---|---|
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| Uruguay | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 15% |
| Student > Bachelor | 12 | 15% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 6 | 7% |
| Other | 14 | 17% |
| Unknown | 21 | 26% |
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|---|---|---|
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| Psychology | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Other | 18 | 22% |
| Unknown | 29 | 35% |