You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The biology of how circumcision reduces HIV susceptibility: broader implications for the prevention field
|
|---|---|
| Published in |
AIDS Research and Therapy, September 2017
|
| DOI | 10.1186/s12981-017-0167-6 |
| Pubmed ID | |
| Authors |
Jessica L. Prodger, Rupert Kaul |
| Abstract |
Circumcision reduces heterosexual HIV-1 acquisition in men by at least 60%. However, the biological mechanisms by which circumcision is protective remain incompletely understood. We test the hypothesis that the sub-preputial microenvironment created by the foreskin drives immune activation in adjacent foreskin tissues, facilitating HIV-1 infection through a combination of epithelial barrier disruption, enhanced dendritic cell maturation, and the recruitment/activation of neutrophils and susceptible CD4 T cell subsets such as Th17 cells. Furthermore, we provide evidence that the genital microbiome may be an important driver of this immune activation. This suggests that new modalities to reduce genital immune activation and/or alter the genital microbiome, used alone or in combination with topical microbicides, may be of significant benefit to HIV prevention. |
X Demographics
The data shown below were collected from the profiles of 82 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 18% |
| Kenya | 6 | 7% |
| South Africa | 3 | 4% |
| United Kingdom | 3 | 4% |
| Germany | 2 | 2% |
| Canada | 2 | 2% |
| New Zealand | 1 | 1% |
| Mali | 1 | 1% |
| South Sudan | 1 | 1% |
| Other | 5 | 6% |
| Unknown | 43 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 75 | 91% |
| Scientists | 3 | 4% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Practitioners (doctors, other healthcare professionals) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 19% |
| Student > Ph. D. Student | 13 | 13% |
| Student > Master | 11 | 11% |
| Student > Postgraduate | 8 | 8% |
| Researcher | 6 | 6% |
| Other | 17 | 17% |
| Unknown | 24 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 16 | 16% |
| Medicine and Dentistry | 13 | 13% |
| Agricultural and Biological Sciences | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Nursing and Health Professions | 6 | 6% |
| Other | 19 | 19% |
| Unknown | 28 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 89. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2024.
All research outputs
#485,305
of 25,728,350 outputs
Outputs from AIDS Research and Therapy
#3
of 647 outputs
Outputs of similar age
#10,100
of 324,474 outputs
Outputs of similar age from AIDS Research and Therapy
#1
of 18 outputs
Altmetric has tracked 25,728,350 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 647 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.