Title |
Sleep deprivation leads to a loss of functional connectivity in frontal brain regions
|
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Published in |
BMC Neuroscience, July 2014
|
DOI | 10.1186/1471-2202-15-88 |
Pubmed ID | |
Authors |
Ilse M Verweij, Nico Romeijn, Dirk JA Smit, Giovanni Piantoni, Eus JW Van Someren, Ysbrand D van der Werf |
Abstract |
The restorative effect of sleep on waking brain activity remains poorly understood. Previous studies have compared overall neural network characteristics after normal sleep and sleep deprivation. To study whether sleep and sleep deprivation might differentially affect subsequent connectivity characteristics in different brain regions, we performed a within-subject study of resting state brain activity using the graph theory framework adapted for the individual electrode level.In balanced order, we obtained high-density resting state electroencephalography (EEG) in 8 healthy participants, during a day following normal sleep and during a day following total sleep deprivation. We computed topographical maps of graph theoretical parameters describing local clustering and path length characteristics from functional connectivity matrices, based on synchronization likelihood, in five different frequency bands. A non-parametric permutation analysis with cluster correction for multiple comparisons was applied to assess significance of topographical changes in clustering coefficient and path length. |
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Geographical breakdown
Country | Count | As % |
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Finland | 6 | 19% |
United States | 6 | 19% |
United Kingdom | 4 | 13% |
Canada | 3 | 9% |
Serbia | 1 | 3% |
Portugal | 1 | 3% |
Australia | 1 | 3% |
Unknown | 10 | 31% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 20 | 63% |
Practitioners (doctors, other healthcare professionals) | 5 | 16% |
Scientists | 5 | 16% |
Science communicators (journalists, bloggers, editors) | 2 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
Unknown | 230 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 16% |
Student > Master | 32 | 14% |
Student > Bachelor | 29 | 13% |
Researcher | 28 | 12% |
Student > Doctoral Student | 16 | 7% |
Other | 28 | 12% |
Unknown | 63 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 42 | 18% |
Neuroscience | 34 | 15% |
Medicine and Dentistry | 20 | 9% |
Agricultural and Biological Sciences | 19 | 8% |
Engineering | 13 | 6% |
Other | 26 | 11% |
Unknown | 78 | 34% |