Title |
Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites
|
---|---|
Published in |
BMC Genomics, July 2014
|
DOI | 10.1186/1471-2164-15-617 |
Pubmed ID | |
Authors |
Frédéric D Chevalier, Claudia LL Valentim, Philip T LoVerde, Timothy JC Anderson |
Abstract |
Identification of parasite genes that underlie traits such as drug resistance and host specificity is challenging using classical linkage mapping approaches. Extreme QTL (X-QTL) methods, originally developed by rodent malaria and yeast researchers, promise to increase the power and simplify logistics of linkage mapping in experimental crosses of schistosomes (or other helminth parasites), because many 1000s of progeny can be analysed, phenotyping is not required, and progeny pools rather than individuals are genotyped. We explored the utility of this method for mapping a drug resistance gene in the human parasitic fluke Schistosoma mansoni. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Burkina Faso | 1 | 2% |
United States | 1 | 2% |
Uruguay | 1 | 2% |
Unknown | 40 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 23% |
Student > Ph. D. Student | 9 | 20% |
Professor > Associate Professor | 4 | 9% |
Student > Bachelor | 3 | 7% |
Student > Doctoral Student | 3 | 7% |
Other | 10 | 23% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 52% |
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Medicine and Dentistry | 3 | 7% |
Environmental Science | 2 | 5% |
Unspecified | 1 | 2% |
Other | 2 | 5% |
Unknown | 6 | 14% |