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In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

Overview of attention for article published in Journal of Translational Medicine, July 2014
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Title
In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients
Published in
Journal of Translational Medicine, July 2014
DOI 10.1186/1479-5876-12-206
Pubmed ID
Authors

Nollaig M Bourke, Mary-Teresa O’Neill, Shahzad Sarwar, Suzanne Norris, Stephen Stewart, John E Hegarty, Nigel J Stevenson, Cliona O’Farrelly

Abstract

Treatment with interferon-alpha (IFN-α) and ribavirin successfully clears hepatitis C virus (HCV) infection in 50% of patients infected with genotype 1. Addition of NS3-4A protease inhibitors (PIs) increases response rates but results in additional side effects and significant economic costs. Here, we hypothesised that in vitro responsiveness of peripheral blood mononuclear cells (PBMCs) to IFN-α stimulation would identify patients who achieved sustained virological response (SVR) on dual therapy alone and thus not require addition of PIs.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Student > Master 4 14%
Researcher 4 14%
Student > Bachelor 3 11%
Professor > Associate Professor 2 7%
Other 3 11%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 11 39%
Immunology and Microbiology 8 29%
Agricultural and Biological Sciences 3 11%
Biochemistry, Genetics and Molecular Biology 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 4 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2014.
All research outputs
#20,233,066
of 22,758,963 outputs
Outputs from Journal of Translational Medicine
#3,307
of 3,979 outputs
Outputs of similar age
#192,446
of 228,570 outputs
Outputs of similar age from Journal of Translational Medicine
#47
of 63 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,979 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.