Title |
The role of hormones and aromatase inhibitors on breast tumor growth and general health in a postmenopausal mouse model
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Published in |
Reproductive Biology and Endocrinology, July 2014
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DOI | 10.1186/1477-7827-12-66 |
Pubmed ID | |
Authors |
Arunkumar Arumugam, Elaine A Lissner, Rajkumar Lakshmanaswamy |
Abstract |
Breast cancer is the most frequently diagnosed cancer in women in the United States. Approximately 70% of breast cancers are diagnosed in postmenopausal women. Major clinical trials and experimental studies showed that aromatase inhibitors are effective against postmenopausal breast cancer. Despite their effectiveness in reducing tumor recurrence, aromatase inhibitors have adverse effects on the cardiovascular system and increase osteoporosis and bone fractures. Our study is aimed at investigating the role of natural steroid hormones on serum cardiovascular and bone resorption markers in an established mouse model mimicking postmenopausal breast cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 15% |
Student > Master | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Student > Postgraduate | 4 | 9% |
Researcher | 4 | 9% |
Other | 4 | 9% |
Unknown | 14 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 28% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Psychology | 3 | 7% |
Nursing and Health Professions | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 5 | 11% |
Unknown | 16 | 35% |