↓ Skip to main content

Clinical risks of St John’s Wort (Hypericum perforatum) co-administration

Overview of attention for article published in Expert Opinion on Drug Metabolism & Toxicology, September 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
video
1 video uploader

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
75 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Clinical risks of St John’s Wort (Hypericum perforatum) co-administration
Published in
Expert Opinion on Drug Metabolism & Toxicology, September 2017
DOI 10.1080/17425255.2017.1378342
Pubmed ID
Authors

Samaneh Soleymani, Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Abdollahi

Abstract

St. John's wort (SJW) is a common medicinal herb used for the treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW, plays an important role in the induction of cytochrome P450 enzymes (CYP) and P-glycoprotein transporter (P-gp), and therefore, affects the pharmacokinetics of various drugs. There are several clinical studies demonstrating the interaction of SJW with the metabolism of conventional drugs which may cause life-threatening events. Areas covered: This review focuses on human studies that have evaluated pharmacokinetic alterations of conventional drugs in concomitant use with different SJW preparations. Expert opinion: SJW preparations have demonstrated clinically important interactions with several classes of conventional drugs such as immunosuppressants, anticancer agents, cardiovascular drugs, oral contraceptives, and lipid lowering agents that caused life-threatening events in several cases. The patient information label on the SJW products should provide enough information regarding the possible risk of interaction. Hyperforin seems to be the major ingredient responsible for CYP and P-gp inducing activity of SJW; thus, hyperforin-free products may be future candidates to decrease SJW's drug interactions.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 28 37%
Student > Master 9 12%
Unspecified 5 7%
Student > Ph. D. Student 5 7%
Other 4 5%
Other 13 17%
Unknown 11 15%
Readers by discipline Count As %
Medicine and Dentistry 16 21%
Pharmacology, Toxicology and Pharmaceutical Science 15 20%
Nursing and Health Professions 9 12%
Agricultural and Biological Sciences 5 7%
Unspecified 4 5%
Other 10 13%
Unknown 16 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2019.
All research outputs
#2,975,488
of 17,059,983 outputs
Outputs from Expert Opinion on Drug Metabolism & Toxicology
#74
of 942 outputs
Outputs of similar age
#52,424
of 233,950 outputs
Outputs of similar age from Expert Opinion on Drug Metabolism & Toxicology
#4
of 21 outputs
Altmetric has tracked 17,059,983 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 942 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,950 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.