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Phylogenomics of Colombian Helicobacter pylori isolates

Overview of attention for article published in Gut Pathogens, September 2017
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Title
Phylogenomics of Colombian Helicobacter pylori isolates
Published in
Gut Pathogens, September 2017
DOI 10.1186/s13099-017-0201-1
Pubmed ID
Authors

Andrés Julián Gutiérrez-Escobar, Esperanza Trujillo, Orlando Acevedo, María Mercedes Bravo

Abstract

During the Spanish colonisation of South America, African slaves and Europeans arrived in the continent with their corresponding load of pathogens, including Helicobacter pylori. Colombian strains have been clustered with the hpEurope population and with the hspWestAfrica subpopulation in multilocus sequence typing (MLST) studies. However, ancestry studies have revealed the presence of population components specific to H. pylori in Colombia. The aim of this study was to perform a thorough phylogenomic analysis to describe the evolution of the Colombian urban H. pylori isolates. A total of 115 genomes of H. pylori were sequenced with Illumina technology from H. pylori isolates obtained in Colombia in a region of high risk for gastric cancer. The genomes were assembled, annotated and underwent phylogenomic analysis with 36 reference strains. Additionally, population differentiation analyses were performed for two bacterial genes. The phylogenetic tree revealed clustering of the Colombian strains with hspWestAfrica and hpEurope, along with three clades formed exclusively by Colombian strains, suggesting the presence of independent evolutionary lines for Colombia. Additionally, the nucleotide diversity of horB and vacA genes from Colombian isolates was lower than in the reference strains and showed a significant genetic differentiation supporting the hypothesis of independent clades with recent evolution. The presence of specific lineages suggest the existence of an hspColombia subtype that emerged from a small and relatively isolated ancestral population that accompanied crossbreeding of human population in Colombia.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 18%
Student > Bachelor 8 16%
Student > Ph. D. Student 5 10%
Student > Master 4 8%
Student > Doctoral Student 4 8%
Other 8 16%
Unknown 12 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 26%
Agricultural and Biological Sciences 9 18%
Medicine and Dentistry 7 14%
Nursing and Health Professions 2 4%
Business, Management and Accounting 1 2%
Other 6 12%
Unknown 12 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#14,955,443
of 23,002,898 outputs
Outputs from Gut Pathogens
#265
of 525 outputs
Outputs of similar age
#187,304
of 316,068 outputs
Outputs of similar age from Gut Pathogens
#7
of 15 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 525 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,068 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.