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Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model

Overview of attention for article published in Clinical Science, August 2017
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Citations

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26 Mendeley
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Title
Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model
Published in
Clinical Science, August 2017
DOI 10.1042/cs20171006
Pubmed ID
Authors

Hao Wang, Desiree Anthony, Selcuk Yatmaz, Odilia Wijburg, Catherine Satzke, Bruce Levy, Ross Vlahos, Steven Bozinovski

Abstract

Formyl peptide receptor 2 (Fpr2/ALX) coordinates the transition from inflammation to resolution during acute infection by binding to distinct ligands including serum amyloid A (SAA) and Resolvin D1 (RvD1). Here, we evaluated the pro-resolving actions of aspirin triggered-RvD1 (AT-RvD1) in an acute co-infection pneumonia model. Co-infection with Streptococcus pneumoniae and influenza A virus (IAV) markedly increased pneumococcal lung load and neutrophilic inflammation during the resolution phase. Fpr2/ALX transcript levels were increased in the lungs of co-infected mice, and immunohistochemistry identified prominent Fpr2/ALX immunoreactivity in bronchial epithelial cells and macrophages. Levels of circulating and lung SAA were also highly increased in co-infected mice. Therapeutic treatment with exogenous AT-RvD1 during the acute phase of infection (day 4-6 post pneumococcal inoculation) significantly reduced the pneumococcal load. AT-RvD1 also significantly reduced neutrophil elastase activity and restored total antimicrobial activity in bronchoalveolar lavage fluid of co-infected mice. Pneumonia severity, as measured by quantifying parenchymal inflammation or alveolitis was significantly reduced with AT-RvD1 treatment, which also reduced the number of infiltrating lung neutrophils and monocytes/macrophages as assessed by flow cytometry. The reduction in distal lung inflammation in AT-RvD1 treated mice was not associated with a significant reduction in inflammatory and chemokine mediators. In summary, we demonstrate that in the co-infection setting, SAA levels were persistently increased and exogenous AT-RvD1 facilitated more rapid clearance of pneumococci in the lungs, whilst concurrently reducing the severity of pneumonia by limiting excessive leukocyte chemotaxis from the infected bronchioles to distal areas of the lungs.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 23%
Student > Ph. D. Student 5 19%
Student > Master 3 12%
Other 2 8%
Student > Doctoral Student 2 8%
Other 2 8%
Unknown 6 23%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Pharmacology, Toxicology and Pharmaceutical Science 3 12%
Immunology and Microbiology 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Unspecified 2 8%
Other 4 15%
Unknown 7 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2019.
All research outputs
#8,558,191
of 13,615,090 outputs
Outputs from Clinical Science
#1,313
of 1,799 outputs
Outputs of similar age
#130,601
of 224,957 outputs
Outputs of similar age from Clinical Science
#17
of 24 outputs
Altmetric has tracked 13,615,090 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,799 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,957 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.