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Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism

Overview of attention for article published in Vaccine, November 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
4 news outlets
blogs
1 blog
twitter
7 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
31 Mendeley
Title
Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism
Published in
Vaccine, November 2014
DOI 10.1016/j.vaccine.2014.07.007
Pubmed ID
Authors

Veljko Veljkovic, Sanja Glisic, Nevena Veljkovic, Tijana Bojic, Ursula Dietrich, Vladimir R. Perovic, Alfonso Colombatti

Abstract

Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies on the cardioprotective effect of influenza vaccines.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Ph. D. Student 6 19%
Student > Bachelor 4 13%
Student > Master 3 10%
Librarian 2 6%
Other 9 29%
Readers by discipline Count As %
Medicine and Dentistry 8 26%
Agricultural and Biological Sciences 7 23%
Unspecified 6 19%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 3 10%
Other 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2017.
All research outputs
#322,683
of 12,639,705 outputs
Outputs from Vaccine
#221
of 10,887 outputs
Outputs of similar age
#6,103
of 192,216 outputs
Outputs of similar age from Vaccine
#5
of 169 outputs
Altmetric has tracked 12,639,705 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,887 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,216 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.