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Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution

Overview of attention for article published in Journal of Biological Chemistry, June 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

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2 tweeters

Citations

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19 Dimensions

Readers on

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32 Mendeley
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1 CiteULike
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Title
Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution
Published in
Journal of Biological Chemistry, June 2014
DOI 10.1074/jbc.m113.528463
Pubmed ID
Authors

Adamantios Mamais, Ruth Chia, Alexandra Beilina, David N. Hauser, Christine Hall, Patrick A. Lewis, Mark R. Cookson, Rina Bandopadhyay

Abstract

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are unknown. Phosphorylation of LRRK2 at Ser(910)/Ser(935) mediates interaction with 14-3-3. Pharmacological inhibition of its kinase activity abolishes Ser(910)/Ser(935) phosphorylation and 14-3-3 binding, and this effect is also mimicked by pathogenic mutations. However, physiological situations where dephosphorylation occurs have not been defined. Here, we show that arsenite or H2O2-induced stresses promote loss of Ser(910)/Ser(935) phosphorylation, which is reversed by phosphatase inhibition. Arsenite-induced dephosphorylation is accompanied by loss of 14-3-3 binding and is observed in wild type, G2019S, and kinase-dead D2017A LRRK2. Arsenite stress stimulates LRRK2 self-association and association with protein phosphatase 1α, decreases kinase activity and GTP binding in vitro, and induces translocation of LRRK2 to centrosomes. Our data indicate that signaling events induced by arsenite and oxidative stress may regulate LRRK2 function.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 34%
Researcher 7 22%
Student > Master 5 16%
Unspecified 4 13%
Student > Postgraduate 2 6%
Other 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 41%
Unspecified 7 22%
Medicine and Dentistry 4 13%
Biochemistry, Genetics and Molecular Biology 3 9%
Chemistry 2 6%
Other 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2014.
All research outputs
#7,348,185
of 12,366,242 outputs
Outputs from Journal of Biological Chemistry
#44,467
of 53,824 outputs
Outputs of similar age
#92,304
of 201,145 outputs
Outputs of similar age from Journal of Biological Chemistry
#209
of 604 outputs
Altmetric has tracked 12,366,242 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 53,824 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 604 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.