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Genetic variation in the CYP2B6 Gene is related to circulating 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study

Overview of attention for article published in Environmental Health, May 2014
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Title
Genetic variation in the CYP2B6 Gene is related to circulating 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study
Published in
Environmental Health, May 2014
DOI 10.1186/1476-069x-13-34
Pubmed ID
Authors

Johanna Penell, Lars Lind, Tove Fall, Anne-Christine Syvänen, Tomas Axelsson, Per Lundmark, Andrew P Morris, Cecilia Lindgren, Anubha Mahajan, Samira Salihovic, Bert van Bavel, Erik Ingelsson, P Monica Lind

Abstract

Since human CYP2B6 has been identified as the major CYP enzyme involved in the metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and that human 2B6 is a highly polymorphic CYP, with known functional variants, we evaluated if circulating concentrations of a major brominated flame retardant, BDE-47, were related to genetic variation in the CYP2B6 gene in a population sample.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Postgraduate 3 19%
Student > Master 2 13%
Student > Ph. D. Student 2 13%
Lecturer > Senior Lecturer 1 6%
Other 2 13%
Unknown 2 13%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Environmental Science 2 13%
Biochemistry, Genetics and Molecular Biology 2 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Computer Science 1 6%
Other 1 6%
Unknown 4 25%