Title |
Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice
|
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Published in |
Parasites & Vectors, November 2013
|
DOI | 10.1186/1756-3305-6-330 |
Pubmed ID | |
Authors |
Jinghui Li, Wenjia Zhuang, Li Cong, Wenjun Shi, Xingyan Cai, Fengjuan Huang, Yiteng Liao, Yiyang Liu, Jun Li, Chunxia Chen, Xiao-Ping Chen |
Abstract |
Schistosomiasis is a chronic infection, where the host immune response to the parasite changes from a predominantly Th1 to Th2 phenotype, when parasite enters the egg stage, restraining the host inflammatory immune responses to achieve a longer survival in the host. On the other hand, the development of Th2 responses causes immunopathological changes such as liver fibrosis. Therefore identification of schistosome-derived Th2 inducing molecules is important in the understanding of pathogenesis of schistosomiasis. A cyclophilin A homologue of Schistosoma japonicum was reported to be an egg-stage specific antigen, but its immunogenicity and immunoregulatory activities remain unknown. |
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United Kingdom | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 15 | 100% |
Demographic breakdown
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Researcher | 3 | 20% |
Student > Ph. D. Student | 3 | 20% |
Other | 2 | 13% |
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