Title |
Mitochondrial haplogroups modify the effect of black carbon on age-related cognitive impairment
|
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Published in |
Environmental Health, May 2014
|
DOI | 10.1186/1476-069x-13-42 |
Pubmed ID | |
Authors |
Elena Colicino, Melinda C Power, David G Cox, Marc G Weisskopf, Lifang Hou, Stacy E Alexeeff, Marco Sanchez-Guerra, Pantel Vokonas, Avron Spiro III, Joel Schwartz, Andrea A Baccarelli |
Abstract |
Traffic-related air pollution has been linked with impaired cognition in older adults, possibly due to effects of oxidative stress on the brain. Mitochondria are the main source of cellular oxidation. Haplogroups in mitochondrial DNA (mtDNA) mark individual differences in oxidative potential and are possible determinants of neurodegeneration. The aim of this study was to investigate whether mtDNA haplogroups determined differential susceptibility to cognitive effects of long-term exposure to black carbon (BC), a marker of traffic-related air pollution. |
Mendeley readers
Geographical breakdown
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Unknown | 69 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 16% |
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Student > Doctoral Student | 4 | 6% |
Other | 10 | 14% |
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