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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activation of a G protein–coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans
|
|---|---|
| Published in |
Nature Immunology, August 2014
|
| DOI | 10.1038/ni.2957 |
| Pubmed ID | |
| Authors |
Olivier Zugasti, Neelanjan Bose, Barbara Squiban, Jérôme Belougne, C Léopold Kurz, Frank C Schroeder, Nathalie Pujol, Jonathan J Ewbank |
| Abstract |
Immune defenses are triggered by microbe-associated molecular patterns or as a result of damage to host cells. The elicitors of immune responses in the nematode Caenorhabditis elegans are unclear. Using a genome-wide RNA-mediated interference (RNAi) screen, we identified the G protein-coupled receptor (GPCR) DCAR-1 as being required for the response to fungal infection and wounding. DCAR-1 acted in the epidermis to regulate the expression of antimicrobial peptides via a conserved p38 mitogen-activated protein kinase pathway. Through targeted metabolomics analysis we identified the tyrosine derivative 4-hydroxyphenyllactic acid (HPLA) as an endogenous ligand. Our findings reveal DCAR-1 and its cognate ligand HPLA to be triggers of the epidermal innate immune response in C. elegans and highlight the ancient role of GPCRs in host defense. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 104 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 25% |
| Researcher | 17 | 16% |
| Student > Master | 13 | 12% |
| Professor > Associate Professor | 9 | 8% |
| Student > Bachelor | 7 | 6% |
| Other | 20 | 18% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 40% |
| Biochemistry, Genetics and Molecular Biology | 21 | 19% |
| Immunology and Microbiology | 12 | 11% |
| Medicine and Dentistry | 4 | 4% |
| Chemistry | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 19 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2014.
All research outputs
#18,375,478
of 22,759,618 outputs
Outputs from Nature Immunology
#3,521
of 3,789 outputs
Outputs of similar age
#164,086
of 229,815 outputs
Outputs of similar age from Nature Immunology
#28
of 33 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,789 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.2. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,815 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.