Title |
Breast-Cancer Risk in Families with Mutations in PALB2
|
---|---|
Published in |
New England Journal of Medicine, August 2014
|
DOI | 10.1056/nejmoa1400382 |
Pubmed ID | |
Authors |
Antonis C. Antoniou, Silvia Casadei, Tuomas Heikkinen, Daniel Barrowdale, Katri Pylkäs, Jonathan Roberts, Andrew Lee, Deepak Subramanian, Kim De Leeneer, Florentia Fostira, Eva Tomiak, Susan L. Neuhausen, Zhi L. Teo, Sofia Khan, Kristiina Aittomäki, Jukka S. Moilanen, Clare Turnbull, Sheila Seal, Arto Mannermaa, Anne Kallioniemi, Geoffrey J. Lindeman, Saundra S. Buys, Irene L. Andrulis, Paolo Radice, Carlo Tondini, Siranoush Manoukian, Amanda E. Toland, Penelope Miron, Jeffrey N. Weitzel, Susan M. Domchek, Bruce Poppe, Kathleen B.M. Claes, Drakoulis Yannoukakos, Patrick Concannon, Jonine L. Bernstein, Paul A. James, Douglas F. Easton, David E. Goldgar, John L. Hopper, Nazneen Rahman, Paolo Peterlongo, Heli Nevanlinna, Mary-Claire King, Fergus J. Couch, Melissa C. Southey, Robert Winqvist, William D. Foulkes, Marc Tischkowitz |
Abstract |
Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. |
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