Report for: Breast-Cancer Risk in Families with Mutations in PALB2

Title	Breast-Cancer Risk in Families with Mutations in PALB2
Published in	New England Journal of Medicine, August 2014
DOI	10.1056/nejmoa1400382
Pubmed ID	25099575
Authors	Antonis C. Antoniou, Silvia Casadei, Tuomas Heikkinen, Daniel Barrowdale, Katri Pylkäs, Jonathan Roberts, Andrew Lee, Deepak Subramanian, Kim De Leeneer, Florentia Fostira, Eva Tomiak, Susan L. Neuhausen, Zhi L. Teo, Sofia Khan, Kristiina Aittomäki, Jukka S. Moilanen, Clare Turnbull, Sheila Seal, Arto Mannermaa, Anne Kallioniemi, Geoffrey J. Lindeman, Saundra S. Buys, Irene L. Andrulis, Paolo Radice, Carlo Tondini, Siranoush Manoukian, Amanda E. Toland, Penelope Miron, Jeffrey N. Weitzel, Susan M. Domchek, Bruce Poppe, Kathleen B.M. Claes, Drakoulis Yannoukakos, Patrick Concannon, Jonine L. Bernstein, Paul A. James, Douglas F. Easton, David E. Goldgar, John L. Hopper, Nazneen Rahman, Paolo Peterlongo, Heli Nevanlinna, Mary-Claire King, Fergus J. Couch, Melissa C. Southey, Robert Winqvist, William D. Foulkes, Marc Tischkowitz
Abstract	Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown.

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Twitter Demographics

The data shown below were collected from the profiles of 230 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United States	88	38%
United Kingdom	18	8%
Spain	14	6%
Italy	6	3%
Canada	5	2%
France	4	2%
Australia	3	1%
Chile	2	<1%
Colombia	2	<1%
Other	18	8%
Unknown	70	30%

Demographic breakdown

Type	Count	As %
Members of the public	144	63%
Scientists	44	19%
Practitioners (doctors, other healthcare professionals)	36	16%
Science communicators (journalists, bloggers, editors)	6	3%

Mendeley readers

The data shown below were compiled from readership statistics for 558 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	4	<1%
Canada	3	<1%
Germany	2	<1%
United Kingdom	2	<1%
Chile	1	<1%
France	1	<1%
Argentina	1	<1%
Finland	1	<1%
Unknown	543	97%

Demographic breakdown

Readers by professional status	Count	As %
Student > Master	108	19%
Researcher	82	15%
Student > Ph. D. Student	75	13%
Student > Bachelor	57	10%
Other	50	9%
Other	103	18%
Unknown	83	15%

Readers by discipline	Count	As %
Medicine and Dentistry	173	31%
Biochemistry, Genetics and Molecular Biology	129	23%
Agricultural and Biological Sciences	105	19%
Nursing and Health Professions	10	2%
Pharmacology, Toxicology and Pharmaceutical Science	8	1%
Other	32	6%
Unknown	101	18%

Attention Score in Context

This research output has an Altmetric Attention Score of 884. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2022.

All research outputs

#13,706

of 21,036,846 outputs

Outputs from New England Journal of Medicine

#636

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Outputs of similar age

#87

of 208,561 outputs

Outputs of similar age from New England Journal of Medicine

of 350 outputs

Altmetric has tracked 21,036,846 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 30,051 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 107.9. This one has done particularly well, scoring higher than 97% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.

We're also able to compare this research output to 350 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.

Breast-Cancer Risk in Families with Mutations in PALB2

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Geographical breakdown

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Attention Score in Context