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An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

Overview of attention for article published in Molecular Cancer, January 2009
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  • Average Attention Score compared to outputs of the same age
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

peer_reviews
1 peer review site

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
33 Mendeley
citeulike
1 CiteULike
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Title
An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals
Published in
Molecular Cancer, January 2009
DOI 10.1186/1476-4598-8-115
Pubmed ID
Authors

Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin, Sherwin Wu, Dajun Yang, Shaomeng Wang, Ayad M Al-Katib

Abstract

MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this study was to evaluate anti-lymphoma activity of MI-319 in WSU-FSCCL, a B-cell follicular lymphoma line. For comparison purpose, MI-319, MI-219 and Nutlin-3 were assessed side by side against FSCCL and three other B-cell hematological tumor cell lines in growth inhibition and gene expression profiling experiments.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 30%
Researcher 9 27%
Student > Bachelor 4 12%
Professor > Associate Professor 3 9%
Other 2 6%
Other 3 9%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 24%
Chemistry 8 24%
Medicine and Dentistry 6 18%
Biochemistry, Genetics and Molecular Biology 4 12%
Computer Science 1 3%
Other 2 6%
Unknown 4 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2016.
All research outputs
#7,833,005
of 12,483,518 outputs
Outputs from Molecular Cancer
#571
of 1,055 outputs
Outputs of similar age
#99,068
of 194,496 outputs
Outputs of similar age from Molecular Cancer
#1
of 7 outputs
Altmetric has tracked 12,483,518 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,055 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,496 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them