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Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

Overview of attention for article published in Nature, December 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
2 tweeters
facebook
2 Facebook pages
wikipedia
23 Wikipedia pages
q&a
1 Q&A thread

Citations

dimensions_citation
643 Dimensions

Readers on

mendeley
1070 Mendeley
citeulike
27 CiteULike
connotea
2 Connotea
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Title
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Published in
Nature, December 2010
DOI 10.1038/nature09725
Pubmed ID
Authors

Peter V. Kharchenko, Artyom A. Alekseyenko, Yuri B. Schwartz, Aki Minoda, Nicole C. Riddle, Jason Ernst, Peter J. Sabo, Erica Larschan, Andrey A. Gorchakov, Tingting Gu, Daniela Linder-Basso, Annette Plachetka, Gregory Shanower, Michael Y. Tolstorukov, Lovelace J. Luquette, Ruibin Xi, Youngsook L. Jung, Richard W. Park, Eric P. Bishop, Theresa K. Canfield, Richard Sandstrom, Robert E. Thurman, David M. MacAlpine, John A. Stamatoyannopoulos, Manolis Kellis, Sarah C. R. Elgin, Mitzi I. Kuroda, Vincenzo Pirrotta, Gary H. Karpen, Peter J. Park

Abstract

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,070 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 47 4%
United Kingdom 17 2%
Spain 11 1%
France 8 <1%
Japan 6 <1%
Germany 6 <1%
Netherlands 3 <1%
China 3 <1%
Sweden 3 <1%
Other 33 3%
Unknown 933 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 329 31%
Researcher 307 29%
Student > Master 84 8%
Professor > Associate Professor 78 7%
Student > Bachelor 63 6%
Other 156 15%
Unknown 53 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 685 64%
Biochemistry, Genetics and Molecular Biology 207 19%
Computer Science 33 3%
Medicine and Dentistry 25 2%
Neuroscience 14 1%
Other 40 4%
Unknown 66 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2020.
All research outputs
#1,433,305
of 16,243,587 outputs
Outputs from Nature
#33,958
of 76,703 outputs
Outputs of similar age
#8,511
of 100,316 outputs
Outputs of similar age from Nature
#501
of 909 outputs
Altmetric has tracked 16,243,587 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 76,703 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 87.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,316 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 909 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.