Title |
Mesalazine in the initial management of severely acutely malnourished children with environmental enteric dysfunction: a pilot randomized controlled trial
|
---|---|
Published in |
BMC Medicine, August 2014
|
DOI | 10.1186/s12916-014-0133-2 |
Pubmed ID | |
Authors |
Kelsey DJ Jones, Barbara Hünten-Kirsch, Ahmed MR Laving, Caroline W Munyi, Moses Ngari, Jenifer Mikusa, Musa M Mulongo, Dennis Odera, H Samira Nassir, Molline Timbwa, Moses Owino, Greg Fegan, Simon H Murch, Peter B Sullivan, John O Warner, James A Berkley |
Abstract |
Environmental enteric dysfunction (EED) is an acquired syndrome of impaired gastrointestinal mucosal barrier function that is thought to play a key role in the pathogenesis of stunting in early life. It has been conceptualized as an adaptive response to excess environmental pathogen exposure. However, it is clinically similar to other inflammatory enteropathies, which result from both host and environmental triggers, and for which immunomodulation is a cornerstone of therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 6 | 46% |
Kenya | 1 | 8% |
Unknown | 6 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 77% |
Practitioners (doctors, other healthcare professionals) | 2 | 15% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | <1% |
Kenya | 1 | <1% |
Unknown | 194 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 11% |
Student > Master | 22 | 11% |
Student > Ph. D. Student | 19 | 10% |
Student > Bachelor | 18 | 9% |
Other | 12 | 6% |
Other | 42 | 21% |
Unknown | 61 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 28% |
Nursing and Health Professions | 15 | 8% |
Agricultural and Biological Sciences | 12 | 6% |
Biochemistry, Genetics and Molecular Biology | 9 | 5% |
Immunology and Microbiology | 7 | 4% |
Other | 26 | 13% |
Unknown | 73 | 37% |