Title |
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor
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Published in |
Respiratory Research, August 2014
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DOI | 10.1186/s12931-014-0093-2 |
Pubmed ID | |
Authors |
Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, Ricardo Erthal Santelli, Aline Soares Freire, Gerson Silva de Lima, Emilson Domingos da Silva, Camila Ignácio da Silva, Verônica Morandi, Patrícia Torres Bozza, Mauricio Younes-Ibrahim, Hugo Caire de Castro Faria Neto, Mauro Velho de Castro Faria |
Abstract |
Leptospiral glycolipoprotein (GLP) is a potent and specific Na/K-ATPase inhibitor. Severe pulmonary form of leptospirosis is characterized by edema, inflammation and intra-alveolar hemorrhage having a dismal prognosis. Resolution of edema and inflammation determines the outcome of lung injury. Na/K-ATPase activity is responsible for edema clearance. This enzyme works as a cell receptor that triggers activation of mitogen-activated protein kinase (MAPK) intracellular signaling pathway. Therefore, injection of GLP into lungs induces injury by triggering inflammation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 17% |
Student > Doctoral Student | 6 | 14% |
Student > Master | 6 | 14% |
Researcher | 4 | 10% |
Professor | 3 | 7% |
Other | 4 | 10% |
Unknown | 12 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 17% |
Veterinary Science and Veterinary Medicine | 4 | 10% |
Immunology and Microbiology | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Nursing and Health Professions | 2 | 5% |
Other | 7 | 17% |
Unknown | 15 | 36% |