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Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor

Overview of attention for article published in Respiratory Research, August 2014
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Mentioned by

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2 tweeters

Citations

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14 Dimensions

Readers on

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28 Mendeley
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Title
Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor
Published in
Respiratory Research, August 2014
DOI 10.1186/s12931-014-0093-2
Pubmed ID
Authors

Cassiano Felippe Gonçalves-de-Albuquerque, Patrícia Burth, Adriana Ribeiro Silva, Isabel Matos Medeiros de Moraes, Flora Magno de Jesus Oliveira, Ricardo Erthal Santelli, Aline Soares Freire, Gerson Silva de Lima, Emilson Domingos da Silva, Camila Ignácio da Silva, Verônica Morandi, Patrícia Torres Bozza, Mauricio Younes-Ibrahim, Hugo Caire de Castro Faria Neto, Mauro Velho de Castro Faria

Abstract

Leptospiral glycolipoprotein (GLP) is a potent and specific Na/K-ATPase inhibitor. Severe pulmonary form of leptospirosis is characterized by edema, inflammation and intra-alveolar hemorrhage having a dismal prognosis. Resolution of edema and inflammation determines the outcome of lung injury. Na/K-ATPase activity is responsible for edema clearance. This enzyme works as a cell receptor that triggers activation of mitogen-activated protein kinase (MAPK) intracellular signaling pathway. Therefore, injection of GLP into lungs induces injury by triggering inflammation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 18%
Student > Bachelor 4 14%
Student > Doctoral Student 4 14%
Researcher 4 14%
Professor 3 11%
Other 2 7%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 5 18%
Immunology and Microbiology 4 14%
Biochemistry, Genetics and Molecular Biology 3 11%
Chemistry 2 7%
Environmental Science 1 4%
Other 5 18%
Unknown 8 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2014.
All research outputs
#9,962,006
of 12,443,993 outputs
Outputs from Respiratory Research
#1,296
of 1,451 outputs
Outputs of similar age
#133,716
of 200,506 outputs
Outputs of similar age from Respiratory Research
#33
of 37 outputs
Altmetric has tracked 12,443,993 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,451 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,506 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.