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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multifunctional Enveloped Mesoporous Silica Nanoparticles for Subcellular Co-delivery of Drug and Therapeutic Peptide
|
|---|---|
| Published in |
Scientific Reports, August 2014
|
| DOI | 10.1038/srep06064 |
| Pubmed ID | |
| Authors |
Guo-Feng Luo, Wei-Hai Chen, Yun Liu, Qi Lei, Ren-Xi Zhuo, Xian-Zheng Zhang |
| Abstract |
A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Mesoporous silica MCM-41 nanoparticles were used as the core for loading antineoplastic drug topotecan (TPT). The surface of nanoparticles was decorated with mitochondria-targeted therapeutic agent (Tpep) containing triphenylphosphonium (TPP) and antibiotic peptide (KLAKLAK)2 via disulfide linkage, followed by coating with a charge reversal polyanion poly(ethylene glycol)-blocked-2,3-dimethylmaleic anhydride-modified poly(L-lysine) (PEG-PLL(DMA)) via electrostatic interaction. It was found that the outer shielding layer could be removed at acidic tumor microenvironment due to the degradation of DMA blocks and the cellular uptake was significantly enhanced by the formation of cationic nanoparticles. After endocytosis, due to the cleavage of disulfide bonds in the presence of intracellular glutathione (GSH), pharmacological agents (Tpep and TPT) could be released from the nanoparticles and subsequently induce specific damage of tumor cell mitochondria and nucleus respectively with remarkable synergistic antitumor effect. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 8% |
| Belgium | 1 | 8% |
| India | 1 | 8% |
| Italy | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 8 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 92% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| India | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 181 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 30% |
| Researcher | 26 | 14% |
| Student > Master | 24 | 13% |
| Student > Bachelor | 12 | 7% |
| Student > Postgraduate | 11 | 6% |
| Other | 25 | 14% |
| Unknown | 30 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 51 | 28% |
| Agricultural and Biological Sciences | 18 | 10% |
| Materials Science | 14 | 8% |
| Engineering | 13 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 7% |
| Other | 31 | 17% |
| Unknown | 45 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2016.
All research outputs
#4,828,815
of 25,477,125 outputs
Outputs from Scientific Reports
#37,772
of 141,277 outputs
Outputs of similar age
#44,735
of 243,921 outputs
Outputs of similar age from Scientific Reports
#193
of 757 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 141,277 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,921 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 757 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.