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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Serum Dickkopf-1 expression level positively correlates with a poor prognosis in breast cancer
|
|---|---|
| Published in |
Diagnostic Pathology, August 2014
|
| DOI | 10.1186/s13000-014-0161-4 |
| Pubmed ID | |
| Authors |
Shao-jie Zhou, Shou-rong Zhuo, Xiao-qing Yang, Chun-xin Qin, Zi-liang Wang |
| Abstract |
BackgroundThe different expression level of Dickkopf-1 (DKK-1) in different cancers shows that the function of DKK-1 depends on the histological type of the cancer cells and the tissue microenvironment. To our knowledge, the serum expression level of DKK-1 in breast cancer is little known.MethodsBlood samples from 125 consecutive patients diagnosed with breast cancer and 53 control subjects from March 2008 to August 2013 were investigated. Serum DKK-1 expression levels were measured by enzyme-linked immunosorbent assay (ELISA). The overall survival (OS) and relapse-free survival (RFS) analyzed by log-rank test, and survival curves were plotted according to Kaplan¿Meier.ResultsThe mean serum level of DKK-1 in patients with breast cancer was 4.99¿±¿1.50 ng/mL, and was significantly higher than that in healthy individuals (1.88¿±¿0.81 ng/mL, P¿<¿0.001). DKK-1 level correlated significantly with TNM stage (P¿=¿0.009), tumor grade (P¿=¿0.02), lymph node metastasis (P¿=¿0.001), and expression of HER2 (P¿=¿0.002). The DKK-1 expression level was classified as high or low in relation to the median value, and patients with breast cancer (n¿=¿125) were divided into a high expression group (n¿=¿63) and a low expression group (n¿=¿62). The Kaplan-Meier method for survival analysis showed that the patients with a high serum DKK-1 level had a poorer OS (48.7% vs. 81.3%, p¿=¿0.01) and RFS (24.3% vs. 71.6%, p¿=¿0.003) than those with a low expression level. The multivariate Cox regression analysis indicated that serum DKK-1 level was independent prognostic factors for OS and RFS.ConclusionsSerum DKK-1 level can be used as a noninvasive biomarker for the prognosis of breast cancer.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_161. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 30% |
| Student > Doctoral Student | 4 | 15% |
| Researcher | 4 | 15% |
| Student > Master | 3 | 11% |
| Student > Bachelor | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 4 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 37% |
| Biochemistry, Genetics and Molecular Biology | 5 | 19% |
| Agricultural and Biological Sciences | 3 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Immunology and Microbiology | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 6 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2014.
All research outputs
#18,376,056
of 22,760,687 outputs
Outputs from Diagnostic Pathology
#758
of 1,122 outputs
Outputs of similar age
#164,820
of 231,138 outputs
Outputs of similar age from Diagnostic Pathology
#22
of 32 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,122 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.