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Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases

Overview of attention for article published in Journal of Biomedical Science, September 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#40 of 765)
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

news
1 news outlet
twitter
5 tweeters

Citations

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25 Dimensions

Readers on

mendeley
78 Mendeley
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Title
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
Published in
Journal of Biomedical Science, September 2017
DOI 10.1186/s12929-017-0380-6
Pubmed ID
Authors

Tzu-Yu Weng, Shang-Yi Anne Tsai, Tsung-Ping Su

Abstract

The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca(2+) signaling between ER and mitochondria and in maintaining the structural integrity of the MAM. The MAM serves as bridges between ER and mitochondria regulating multiple functions such as Ca(2+) transfer, energy exchange, lipid synthesis and transports, and protein folding that are pivotal to cell survival and defense. Recently, emerging evidences indicate that the MAM is critical in maintaining neuronal homeostasis. Thus, given the specific localization of the Sig-1R at the MAM, we highlight and propose that the direct or indirect regulations of the Sig-1R on mitochondrial functions may relate to neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). In addition, the promising use of Sig-1R ligands to rescue mitochondrial dysfunction-induced neurodegeneration is addressed.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 18%
Student > Ph. D. Student 12 15%
Researcher 10 13%
Student > Master 9 12%
Other 6 8%
Other 9 12%
Unknown 18 23%
Readers by discipline Count As %
Neuroscience 19 24%
Biochemistry, Genetics and Molecular Biology 19 24%
Pharmacology, Toxicology and Pharmaceutical Science 8 10%
Medicine and Dentistry 6 8%
Agricultural and Biological Sciences 3 4%
Other 5 6%
Unknown 18 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2020.
All research outputs
#1,678,253
of 15,736,309 outputs
Outputs from Journal of Biomedical Science
#40
of 765 outputs
Outputs of similar age
#43,314
of 277,253 outputs
Outputs of similar age from Journal of Biomedical Science
#1
of 3 outputs
Altmetric has tracked 15,736,309 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 765 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,253 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them