Title |
Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer
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Published in |
BMC Genomics, August 2014
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DOI | 10.1186/1471-2164-15-709 |
Pubmed ID | |
Authors |
Karen H Hales, Sheree C Speckman, Nawneet K Kurrey, Dale B Hales |
Abstract |
The laying hen model of spontaneous epithelial ovarian cancer (EOC) is unique in that it is the only model that enables observations of early events in disease progression and is therefore also uniquely suited for chemoprevention trials. Previous studies on the effect of dietary flaxseed in laying hens have revealed the potential for both amelioration and prevention of ovarian cancer. The objective of this study was to assess the effect of flaxseed on genes and pathways that are dysregulated in tumors. We have used a bioinformatics approach to identify these genes, followed by qPCR validation, immunohistochemical localization, and in situ hybridization to visualize expression in normal ovaries and tumors from animals fed a control diet or a diet containing 10% flaxseed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 18% |
Student > Doctoral Student | 4 | 14% |
Researcher | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Student > Postgraduate | 3 | 11% |
Other | 3 | 11% |
Unknown | 7 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 25% |
Agricultural and Biological Sciences | 4 | 14% |
Medicine and Dentistry | 3 | 11% |
Nursing and Health Professions | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 3 | 11% |
Unknown | 7 | 25% |