Title |
The role of glucagon on type 2 diabetes at a glance
|
---|---|
Published in |
Diabetology & Metabolic Syndrome, August 2014
|
DOI | 10.1186/1758-5996-6-91 |
Pubmed ID | |
Authors |
Amélio F Godoy-Matos |
Abstract |
The opposite effects of insulin and glucagon in fuel homeostasis, the paracrine/endocrine inhibitory effects of insulin on glucagon secretion and the hyperglucagonemia in the pathogenesis of type 2 diabetes (T2D) have long been recognized. Inappropriately increased alpha-cell function importantly contributes to hyperglycemia and reflects the loss of tonic restraint normally exerted by high local concentrations of insulin on alpha-cells, possibly as a result of beta-cell failure and alpha-cell insulin resistance, but additional mechanisms, such as the participation of incretin hormones in this response, have also been suggested. Three classes of drugs already available for clinical use address the abnormalities of glucagon secretion in T2D, namely, the GLP-1 receptor agonists (GLP-1RA), the inhibitors of dipeptidyl peptidase-4 (DPP-4i) and the amylin agonist pramlintide; it has been proposed that the glucagonostatic and insulinotropic effects of GLP-1RA equally contribute to their hypoglycemic efficacy. In this review, the control of glucagon secretion and its participation in T2D pathogenesis are summarized. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 25% |
Canada | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iraq | 1 | <1% |
Sweden | 1 | <1% |
Russia | 1 | <1% |
Unknown | 166 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 22% |
Student > Master | 23 | 14% |
Researcher | 20 | 12% |
Student > Bachelor | 18 | 11% |
Student > Doctoral Student | 10 | 6% |
Other | 22 | 13% |
Unknown | 38 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 21% |
Agricultural and Biological Sciences | 35 | 21% |
Biochemistry, Genetics and Molecular Biology | 23 | 14% |
Chemistry | 7 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Other | 20 | 12% |
Unknown | 44 | 26% |