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Casein haplotypes and their association with milk production traits in Norwegian Red cattle.

Overview of attention for article published in Genetics Selection Evolution, February 2009
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Title
Casein haplotypes and their association with milk production traits in Norwegian Red cattle.
Published in
Genetics Selection Evolution, February 2009
DOI 10.1186/1297-9686-41-24
Pubmed ID
Authors

Nilsen H, Olsen HG, Hayes B, Sehested E, Svendsen M, Nome T, Meuwissen T, Lien S, Heidi Nilsen, Hanne Olsen, Ben Hayes, Erling Sehested, Morten Svendsen, Torfinn Nome, Theo Meuwissen, Sigbjørn Lien

Abstract

A high resolution SNP map was constructed for the bovine casein region to identify haplotype structures and study associations with milk traits in Norwegian Red cattle. Our analyses suggest separation of the casein cluster into two haplotype blocks, one consisting of the CSN1S1, CSN2 and CSN1S2 genes and another one consisting of the CSN3 gene. Highly significant associations with both protein and milk yield were found for both single SNPs and haplotypes within the CSN1S1-CSN2-CSN1S2 haplotype block. In contrast, no significant association was found for single SNPs or haplotypes within the CSN3 block. Our results point towards CSN2 and CSN1S2 as the most likely loci harbouring the underlying causative DNA variation. In our study, the most significant results were found for the SNP CSN2_67 with the C allele consistently associated with both higher protein and milk yields. CSN2_67 calls a C to an A substitution at codon 67 in beta-casein gene resulting in histidine replacing proline in the amino acid sequence. This polymorphism determines the protein variants A1/B (CSN2_67 A allele) versus A2/A3 (CSN2_67 C allele). Other studies have suggested that a high consumption of A1/B milk may affect human health by increasing the risk of diabetes and heart diseases. Altogether these results argue for an increase in the frequency of the CSN2_67 C allele or haplotypes containing this allele in the Norwegian Red cattle population by selective breeding.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 4%
India 1 1%
Ireland 1 1%
France 1 1%
Norway 1 1%
Canada 1 1%
Egypt 1 1%
United States 1 1%
Poland 1 1%
Other 0 0%
Unknown 73 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 23%
Researcher 15 18%
Student > Master 10 12%
Student > Bachelor 7 8%
Professor 6 7%
Other 22 26%
Unknown 5 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 60%
Medicine and Dentistry 6 7%
Biochemistry, Genetics and Molecular Biology 6 7%
Veterinary Science and Veterinary Medicine 4 5%
Unspecified 2 2%
Other 6 7%
Unknown 10 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2014.
All research outputs
#9,075,389
of 11,335,855 outputs
Outputs from Genetics Selection Evolution
#289
of 391 outputs
Outputs of similar age
#130,533
of 193,910 outputs
Outputs of similar age from Genetics Selection Evolution
#7
of 11 outputs
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