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In vitro anti-tuberculosis activity of azole drugs against Mycobacterium tuberculosis clinical isolates

Overview of attention for article published in Revista Argentina de Microbiología, October 2017
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About this Attention Score

  • Among the highest-scoring outputs from this source (#27 of 228)
  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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6 tweeters

Citations

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8 Dimensions

Readers on

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41 Mendeley
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Title
In vitro anti-tuberculosis activity of azole drugs against Mycobacterium tuberculosis clinical isolates
Published in
Revista Argentina de Microbiología, October 2017
DOI 10.1016/j.ram.2017.02.008
Pubmed ID
Authors

Belén R. Imperiale, Ángel A. Cataldi, Nora S. Morcillo

Abstract

Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and extensively-drug resistant tuberculosis (M/XDR-TB). It was previously reported that azole drugs are active against M. tuberculosis. For that reason, the aims of this study were to determine the in vitro activity of azole drugs, imidazole (clotrimazole, CLO and econazole, ECO) and nitroimidazole (metronidazole, MZ and ipronidazole, IPZ), against a collection of MDR M. tuberculosis clinical isolates; and to analyze their potential use in both the LTB and the active forms of M/XDR-TB treatments. A total of 55 MDR M. tuberculosis isolates and H37Rv were included. MZ and IPZ activity against M. tuberculosis isolates were tested using anaerobic culture conditions. The activity of ECO and CLO was measured by the minimal inhibitory concentration (MIC) using a microdilution colorimetric method. MZ and IPZ showed bacteriostatic activity against M. tuberculosis strains. MIC50 and MIC90 to ECO was 4.0μg/ml, while MIC50 to CLO was 4.0μg/ml and MIC90 was 8.0μg/ml respectively. All azole compounds tested in the study showed inhibitory activity against MDR M. tuberculosis clinical isolates.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 17%
Researcher 5 12%
Student > Ph. D. Student 5 12%
Student > Master 4 10%
Unspecified 3 7%
Other 5 12%
Unknown 12 29%
Readers by discipline Count As %
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 5 12%
Immunology and Microbiology 5 12%
Business, Management and Accounting 3 7%
Unspecified 3 7%
Other 6 15%
Unknown 13 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2018.
All research outputs
#8,422,847
of 16,037,125 outputs
Outputs from Revista Argentina de Microbiología
#27
of 228 outputs
Outputs of similar age
#113,233
of 278,425 outputs
Outputs of similar age from Revista Argentina de Microbiología
#2
of 16 outputs
Altmetric has tracked 16,037,125 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 228 research outputs from this source. They receive a mean Attention Score of 1.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.