↓ Skip to main content

Deletion of Prostaglandin E2 Synthesizing Enzymes in Brain Endothelial Cells Attenuates Inflammatory Fever

Overview of attention for article published in Journal of Neuroscience, August 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
7 news outlets
blogs
1 blog
twitter
3 tweeters
weibo
3 weibo users
facebook
1 Facebook page

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
38 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Deletion of Prostaglandin E2 Synthesizing Enzymes in Brain Endothelial Cells Attenuates Inflammatory Fever
Published in
Journal of Neuroscience, August 2014
DOI 10.1523/jneurosci.1838-14.2014
Pubmed ID
Authors

Daniel Björk Wilhelms, Milen Kirilov, Elahe Mirrasekhian, Anna Eskilsson, Unn Örtegren Kugelberg, Christine Klar, Dirk A. Ridder, Harvey R. Herschman, Markus Schwaninger, Anders Blomqvist, David Engblom

Abstract

Fever is a hallmark of inflammatory and infectious diseases. The febrile response is triggered by prostaglandin E2 synthesis mediated by induced expression of the enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1). The cellular source for pyrogenic PGE2 remains a subject of debate; several hypotheses have been forwarded, including immune cells in the periphery and in the brain, as well as the brain endothelium. Here we generated mice with selective deletion of COX-2 and mPGES1 in brain endothelial cells. These mice displayed strongly attenuated febrile responses to peripheral immune challenge. In contrast, inflammation-induced hypoactivity was unaffected, demonstrating the physiological selectivity of the response to the targeted gene deletions. These findings demonstrate that PGE2 synthesis in brain endothelial cells is critical for inflammation-induced fever.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 24%
Student > Master 8 21%
Student > Bachelor 7 18%
Researcher 4 11%
Unspecified 3 8%
Other 7 18%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Agricultural and Biological Sciences 6 16%
Biochemistry, Genetics and Molecular Biology 6 16%
Pharmacology, Toxicology and Pharmaceutical Science 5 13%
Neuroscience 4 11%
Other 8 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2015.
All research outputs
#63,898
of 4,888,368 outputs
Outputs from Journal of Neuroscience
#246
of 10,262 outputs
Outputs of similar age
#3,034
of 128,170 outputs
Outputs of similar age from Journal of Neuroscience
#18
of 331 outputs
Altmetric has tracked 4,888,368 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,262 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 128,170 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 331 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.