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Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease

Overview of attention for article published in Journal of Alzheimer's Disease, December 2014
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Title
Skewed X-Chromosome Inactivation in Women Affected by Alzheimer's Disease
Published in
Journal of Alzheimer's Disease, December 2014
DOI 10.3233/jad-141674
Pubmed ID
Authors

Vladan Bajic, Vesna Mandusic, Elka Stefanova, Ana Bozovic, Radoslav Davidovic, Lada Zivkovic, Andrea Cabarkapa, Biljana Spremo-Potparevic

Abstract

X-chromosome instability has been a long established feature in Alzheimer's disease (AD). Premature centromere division and aneuploidy of the X-chromosome has been found in peripheral blood lymphocytes and neuronal tissue in female AD patients. Interestingly, only one chromosome of the X pair has been affected. These results raised a question, "Is the X-chromosome inactivation pattern altered in peripheral blood lymphocytes of women affected by AD?" To address this question, we analyzed the methylation status of androgen receptor promoter which may show us any deviation from the 50 : 50% X inactivation status in peripheral blood lymphocytes of women with AD. Our results showed skewed inactivation patterns (>90%). These findings suggest that an epigenetic alteration on the inactivation centers of the X-chromosome (or skewing) relates not only to aging, by might be a novel property that could account for the higher incidence of AD in women.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Professor 4 17%
Student > Master 4 17%
Student > Bachelor 3 13%
Researcher 2 8%
Student > Ph. D. Student 2 8%
Other 5 21%
Unknown 4 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 21%
Medicine and Dentistry 4 17%
Neuroscience 3 13%
Agricultural and Biological Sciences 2 8%
Psychology 1 4%
Other 3 13%
Unknown 6 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2014.
All research outputs
#10,124,101
of 11,409,342 outputs
Outputs from Journal of Alzheimer's Disease
#2,993
of 3,176 outputs
Outputs of similar age
#158,593
of 194,401 outputs
Outputs of similar age from Journal of Alzheimer's Disease
#71
of 86 outputs
Altmetric has tracked 11,409,342 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,176 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,401 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.