Title |
Possible Role of Interleukin-1β in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies
|
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Published in |
PLoS Computational Biology, August 2014
|
DOI | 10.1371/journal.pcbi.1003798 |
Pubmed ID | |
Authors |
Gang Zhao, Gitanjali Dharmadhikari, Kathrin Maedler, Michael Meyer-Hermann |
Abstract |
Increasing evidence of a role of chronic inflammation in type 2 diabetes progression has led to the development of therapies targeting the immune system. We develop a model of interleukin-1β dynamics in order to explain principles of disease onset. The parameters in the model are derived from in vitro experiments and patient data. In the framework of this model, an IL-1β switch is sufficient and necessary to account for type 2 diabetes onset. The model suggests that treatments targeting glucose bear the potential of stopping progression from pre-diabetes to overt type 2 diabetes. However, once in overt type 2 diabetes, these treatments have to be complemented by adjuvant anti-inflammatory therapies in order to stop or decelerate disease progression. Moreover, the model suggests that while glucose-lowering therapy needs to be continued all the way, dose and duration of the anti-inflammatory therapy needs to be specifically controlled. The model proposes a framework for the discussion of clinical trial outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Norway | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Unknown | 107 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 21 | 19% |
Student > Master | 13 | 12% |
Student > Ph. D. Student | 9 | 8% |
Researcher | 6 | 6% |
Student > Doctoral Student | 3 | 3% |
Other | 13 | 12% |
Unknown | 43 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 15% |
Medicine and Dentistry | 15 | 14% |
Agricultural and Biological Sciences | 13 | 12% |
Immunology and Microbiology | 4 | 4% |
Nursing and Health Professions | 2 | 2% |
Other | 7 | 6% |
Unknown | 51 | 47% |