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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Overview of attention for article published in Science, August 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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1102 Dimensions

Readers on

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1547 Mendeley
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4 CiteULike
Title
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Published in
Science, August 2014
DOI 10.1126/science.1259657
Pubmed ID
Authors

Stephen K Gire, Augustine Goba, Kristian G Andersen, Rachel S G Sealfon, Daniel J Park, Lansana Kanneh, Simbirie Jalloh, Mambu Momoh, Mohamed Fullah, Gytis Dudas, Shirlee Wohl, Lina M Moses, Nathan L Yozwiak, Sarah Winnicki, Christian B Matranga, Christine M Malboeuf, James Qu, Adrianne D Gladden, Stephen F Schaffner, Xiao Yang, Pan-Pan Jiang, Mahan Nekoui, Andres Colubri, Moinya Ruth Coomber, Mbalu Fonnie, Alex Moigboi, Michael Gbakie, Fatima K Kamara, Veronica Tucker, Edwin Konuwa, Sidiki Saffa, Josephine Sellu, Abdul Azziz Jalloh, Alice Kovoma, James Koninga, Ibrahim Mustapha, Kandeh Kargbo, Momoh Foday, Mohamed Yillah, Franklyn Kanneh, Willie Robert, James L B Massally, Sinéad B Chapman, James Bochicchio, Cheryl Murphy, Chad Nusbaum, Sarah Young, Bruce W Birren, Donald S Grant, John S Scheiffelin, Eric S Lander, Christian Happi, Sahr M Gevao, Andreas Gnirke, Andrew Rambaut, Robert F Garry, S Humarr Khan, Pardis C Sabeti

Abstract

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.

X Demographics

X Demographics

The data shown below were collected from the profiles of 1,352 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,547 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 37 2%
United Kingdom 11 <1%
Germany 7 <1%
France 5 <1%
Canada 5 <1%
Brazil 4 <1%
China 4 <1%
Japan 3 <1%
India 3 <1%
Other 24 2%
Unknown 1444 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 300 19%
Researcher 287 19%
Student > Bachelor 240 16%
Student > Master 204 13%
Other 78 5%
Other 267 17%
Unknown 171 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 541 35%
Biochemistry, Genetics and Molecular Biology 215 14%
Medicine and Dentistry 185 12%
Immunology and Microbiology 97 6%
Engineering 46 3%
Other 252 16%
Unknown 211 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2234. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2024.
All research outputs
#3,795
of 25,587,485 outputs
Outputs from Science
#200
of 83,122 outputs
Outputs of similar age
#18
of 248,049 outputs
Outputs of similar age from Science
#2
of 906 outputs
Altmetric has tracked 25,587,485 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,122 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,049 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 906 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.