Title |
Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization
|
---|---|
Published in |
Critical Care, August 2014
|
DOI | 10.1186/s13054-014-0481-5 |
Pubmed ID | |
Authors |
Catherine Chen, Marin H Kollef |
Abstract |
Intravenous fluids (IVFs) represent a basic therapeutic intervention utilized in septic shock. Unfortunately, the optimal method for administering IVFs to maximize patient outcomes is unknown. A meta-analysis of four randomized trials of goal-directed therapy did not demonstrate a significant reduction in mortality (odds ratio 0.609; 95% confidence interval 0.363 to 1.020; P = 0.059), whereas 18 trials with historical controls showed a significant increase in survival (odds ratio 0.580; 95% confidence interval 0.501 to 0.672; P < 0.0001). Based on these data, clinicians should be aware of the potential for harm due to the excessive administration of IVFs to patients with septic shock. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 22% |
United States | 4 | 22% |
Spain | 1 | 6% |
Brazil | 1 | 6% |
Canada | 1 | 6% |
Italy | 1 | 6% |
Qatar | 1 | 6% |
Mexico | 1 | 6% |
Greece | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 33% |
Practitioners (doctors, other healthcare professionals) | 5 | 28% |
Scientists | 4 | 22% |
Science communicators (journalists, bloggers, editors) | 3 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 2% |
Belgium | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 47 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 9 | 18% |
Other | 7 | 14% |
Student > Master | 7 | 14% |
Student > Bachelor | 5 | 10% |
Professor > Associate Professor | 4 | 8% |
Other | 9 | 18% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 33 | 66% |
Nursing and Health Professions | 2 | 4% |
Arts and Humanities | 1 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 3 | 6% |
Unknown | 9 | 18% |