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A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Overview of attention for article published in Nature Communications, September 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
9 news outlets
blogs
1 blog
twitter
31 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
49 Dimensions

Readers on

mendeley
112 Mendeley
Title
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
Published in
Nature Communications, September 2017
DOI 10.1038/s41467-017-00737-8
Pubmed ID
Authors

Chao Shan, Antonio E. Muruato, Brett W. Jagger, Justin Richner, Bruno T. D. Nunes, Daniele B. A. Medeiros, Xuping Xie, Jannyce G. C. Nunes, Kaitlyn M. Morabito, Wing-Pui Kong, Theodore C. Pierson, Alan D. Barrett, Scott C. Weaver, Shannan L. Rossi, Pedro F. C. Vasconcelos, Barney S. Graham, Michael S. Diamond, Pei-Yong Shi

Abstract

Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3'UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3'UTR-LAV is warranted for humans.Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.

Twitter Demographics

The data shown below were collected from the profiles of 31 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 112 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 21%
Student > Bachelor 19 17%
Unspecified 17 15%
Student > Ph. D. Student 17 15%
Student > Master 15 13%
Other 21 19%
Readers by discipline Count As %
Immunology and Microbiology 24 21%
Biochemistry, Genetics and Molecular Biology 23 21%
Unspecified 21 19%
Agricultural and Biological Sciences 17 15%
Medicine and Dentistry 12 11%
Other 15 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 90. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2018.
All research outputs
#176,493
of 13,334,614 outputs
Outputs from Nature Communications
#3,227
of 23,636 outputs
Outputs of similar age
#7,678
of 270,151 outputs
Outputs of similar age from Nature Communications
#28
of 415 outputs
Altmetric has tracked 13,334,614 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,636 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,151 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 415 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.