Title |
Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats
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Published in |
Arquivos de Neuro-Psiquiatria, December 2008
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DOI | 10.1590/s0004-282x2008000600015 |
Pubmed ID | |
Authors |
Yaima del Carmen Garrido Sanabria, Gustavo Adolfo Argañaraz, Eliangela Lima, Margareth Rose Priel, Edvaldo da Silva Trindade, Luana Mazzacoratti Loeb, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Débora Amado, Maria da Graça Naffah-Mazzacoratti |
Abstract |
Neurogenesis in the dentate gyrus (DG) has attracted attention since abnormal supragranular mossy fiber sprouting occurs in the same region, in temporal lobe epilepsy. Thus, we submitted developing rats to pilocarpine-induced status epilepticus (SE) to study the relationship between neurogenesis and mossy fiber sprouting. Groups were submitted to SE at: I-P9, II-P7, P8 and P9, III-P17 e IV-P21. Neurogenesis was quantified using BrdU protocol and confirmed through double staining, using neuronal pentraxin. Other animals were monitored by video system until P120 and their brain was studied (Timm and Nissl staining). The neurogenesis at P17 (p=0.007) and P21 (p=0.006) were increased. However, only P21 group showed recurrent seizures and the mossy fiber sprouting in the same region, during adult life, while P17 did not. Thus, our results suggest that neurogenesis is not related to mossy fiber sprouting neither to recurrent spontaneous seizures in pilocarpine model. |
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