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Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions inC9ORF72gene

Overview of attention for article published in Neuropathology & Applied Neurobiology, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
19 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
43 Dimensions

Readers on

mendeley
96 Mendeley
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Title
Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions inC9ORF72gene
Published in
Neuropathology & Applied Neurobiology, April 2015
DOI 10.1111/nan.12178
Pubmed ID
Authors

Atik Baborie, Timothy D. Griffiths, Evelyn Jaros, Robert Perry, Ian G. McKeith, David J. Burn, Masami Masuda-Suzukake, Masato Hasegawa, Sara Rollinson, Stuart Pickering-Brown, Andrew C. Robinson, Yvonne S. Davidson, David M. A. Mann

Abstract

Frontotemporal lobar degeneration (FTLD) and Motor Neuron Disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP-43 negative but immunoreactive for p62 and dipeptide repeat proteins (DPR), these being generated by a non-ATG RAN translation of the expanded region of the gene.

Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 95 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 28%
Student > Bachelor 15 16%
Researcher 13 14%
Student > Master 12 13%
Student > Doctoral Student 8 8%
Other 10 10%
Unknown 11 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 24%
Neuroscience 22 23%
Medicine and Dentistry 17 18%
Biochemistry, Genetics and Molecular Biology 12 13%
Nursing and Health Professions 2 2%
Other 6 6%
Unknown 14 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2016.
All research outputs
#1,649,532
of 15,438,352 outputs
Outputs from Neuropathology & Applied Neurobiology
#125
of 860 outputs
Outputs of similar age
#23,788
of 203,230 outputs
Outputs of similar age from Neuropathology & Applied Neurobiology
#3
of 29 outputs
Altmetric has tracked 15,438,352 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 860 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,230 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.