Title |
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
|
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Published in |
Genome Medicine, September 2017
|
DOI | 10.1186/s13073-017-0475-4 |
Pubmed ID | |
Authors |
Dianne Nicol, Lisa Eckstein, Michael Morrison, Jacob S. Sherkow, Margaret Otlowski, Tess Whitton, Tania Bubela, Kathryn P. Burdon, Don Chalmers, Sarah Chan, Jac Charlesworth, Christine Critchley, Merlin Crossley, Sheryl de Lacey, Joanne L. Dickinson, Alex W. Hewitt, Joanne Kamens, Kazuto Kato, Erika Kleiderman, Satoshi Kodama, John Liddicoat, David A. Mackey, Ainsley J. Newson, Jane Nielsen, Jennifer K. Wagner, Rebekah E. McWhirter |
Abstract |
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 10 | 14% |
United States | 10 | 14% |
Canada | 9 | 12% |
Australia | 5 | 7% |
Belgium | 1 | 1% |
Finland | 1 | 1% |
France | 1 | 1% |
Russia | 1 | 1% |
Portugal | 1 | 1% |
Other | 0 | 0% |
Unknown | 34 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 40 | 55% |
Scientists | 23 | 32% |
Practitioners (doctors, other healthcare professionals) | 5 | 7% |
Science communicators (journalists, bloggers, editors) | 5 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 91 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 15% |
Student > Bachelor | 13 | 14% |
Researcher | 11 | 12% |
Student > Ph. D. Student | 9 | 10% |
Student > Doctoral Student | 4 | 4% |
Other | 15 | 16% |
Unknown | 25 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 16% |
Social Sciences | 9 | 10% |
Medicine and Dentistry | 8 | 9% |
Agricultural and Biological Sciences | 7 | 8% |
Arts and Humanities | 4 | 4% |
Other | 19 | 21% |
Unknown | 29 | 32% |