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Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, August 2017
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Title
Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil
Published in
Revista da Sociedade Brasileira de Medicina Tropical, August 2017
DOI 10.1590/0037-8682-0450-2016
Pubmed ID
Authors

Valéria Miranda Avanzi, Bianca Arão Vicente, Nayara Carvalho Polido Beloto, Monica Maria Gomes-da-Silva, Clea Elisa Lopes Ribeiro, Felipe Francisco Tuon, Luine Rosele Renaud Vidal, Meri Bordignon Nogueira, Sonia Mara Raboni

Abstract

HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil. Clinical and epidemiological data were evaluated by a review of medical records. Periodic blood draws were taken to determine the viral and host characteristics. This study included 38 patients with HIV/HBV or HIV/HCV coinfection; the median age was 49 years. Thirty-seven (97.4%) were on antiretroviral therapy, 32 (84.2%) had an undetectable viral load, a median CD4+ T-cell count of 452 cells/mm3. HIV-1 subtyping showed 47.4 and 31.6% of patients with subtypes C and B, respectively. Analysis of viral co-receptor usage showed a predominance of the R5 variant (64.7%), with no significant difference between the subtypes. Twenty patients with HIV/HCV coinfection were eligible to receive HCV therapy with pegylated-interferon-alpha plus ribavirin, and 10/20 (50%) of them achieved sustained virological response. SNPs of IL28B were evaluated in 93.3% of patients with HIV/HCV coinfection, and 17 (60.7%) presented the CC genotype. In the present case series, a higher frequency of HIV subtype C was found in coinfected patients. However such findings need to be prospectively evaluated with the inclusion of data from regional multicenter analyses.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 26%
Student > Ph. D. Student 6 14%
Student > Bachelor 5 12%
Other 4 10%
Student > Doctoral Student 2 5%
Other 5 12%
Unknown 9 21%
Readers by discipline Count As %
Medicine and Dentistry 11 26%
Biochemistry, Genetics and Molecular Biology 7 17%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Nursing and Health Professions 3 7%
Immunology and Microbiology 2 5%
Other 2 5%
Unknown 13 31%