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Puerperal brain cryptococcoma in an HIV-negative woman successfully treated with fluconazole: a case report

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, April 2014
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Title
Puerperal brain cryptococcoma in an HIV-negative woman successfully treated with fluconazole: a case report
Published in
Revista da Sociedade Brasileira de Medicina Tropical, April 2014
DOI 10.1590/0037-8682-0215-2013
Pubmed ID
Authors

José Edward Hagan, Jesângeli Sousa Dias, José Caetano Villasboas-Bisneto, Melissa Barreto Falcão, Albert Icksang Ko, Guilherme Sousa Ribeiro

Abstract

Cryptococcus spp. cerebral abscesses are uncommon in immunocompetent subjects. The recommended induction treatment is the administration of amphotericin B plus flucytosine combined with resection for lesions ≥3cm. In this paper, we describe an HIV-negative woman diagnosed with a large cryptococcoma in the immediate postpartum period. The lesion was not resected, and due to amphotericin B intolerance, she received an extended course of fluconazole monotherapy. There was no disease recurrence during the 4 years of follow-up. The abrupt onset of her symptoms following delivery suggests that she developed a postpartum immune reconstitution syndrome. This case also demonstrates that in specific situations fluconazole monotherapy can be attempted in immunocompetent patients with cryptococcoma.

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Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Netherlands 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 17%
Student > Bachelor 4 11%
Other 3 9%
Student > Postgraduate 3 9%
Student > Ph. D. Student 3 9%
Other 6 17%
Unknown 10 29%
Readers by discipline Count As %
Medicine and Dentistry 22 63%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Unknown 12 34%