You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inflammation in gout: mechanisms and therapeutic targets
|
|---|---|
| Published in |
Nature Reviews Rheumatology, September 2017
|
| DOI | 10.1038/nrrheum.2017.155 |
| Pubmed ID | |
| Authors |
Alexander K. So, Fabio Martinon |
| Abstract |
The acute symptoms of gout are triggered by the inflammatory response to monosodium urate crystals, mediated principally by macrophages and neutrophils. Innate immune pathways are of key importance in the pathogenesis of gout, in particular the activation of the NLRP3 inflammasome, which leads to the release of IL-1β and other pro-inflammatory cytokines. The orchestration of this pro-inflammatory cascade involves multiple intracellular and extracellular receptors and enzymes interacting with environmental influences that modulate the inflammatory state. Furthermore, the resolution of inflammation in gout is becoming better understood. This Review highlights recent advances in our understanding of both positive and negative regulatory pathways, as well as the genetic and environmental factors that modulate the inflammatory response. Some of these pathways can be manipulated and present novel therapeutic opportunities for the treatment of acute gout attacks. |
X Demographics
The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 11 | 20% |
| Spain | 4 | 7% |
| Colombia | 2 | 4% |
| United Kingdom | 2 | 4% |
| Ecuador | 2 | 4% |
| Peru | 2 | 4% |
| Dominican Republic | 2 | 4% |
| Chile | 2 | 4% |
| India | 2 | 4% |
| Other | 9 | 16% |
| Unknown | 18 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 71% |
| Scientists | 9 | 16% |
| Practitioners (doctors, other healthcare professionals) | 6 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 288 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 288 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 38 | 13% |
| Student > Ph. D. Student | 31 | 11% |
| Researcher | 23 | 8% |
| Student > Master | 22 | 8% |
| Other | 19 | 7% |
| Other | 56 | 19% |
| Unknown | 99 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 65 | 23% |
| Biochemistry, Genetics and Molecular Biology | 28 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 28 | 10% |
| Immunology and Microbiology | 16 | 6% |
| Agricultural and Biological Sciences | 14 | 5% |
| Other | 25 | 9% |
| Unknown | 112 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2018.
All research outputs
#1,205,489
of 25,658,541 outputs
Outputs from Nature Reviews Rheumatology
#246
of 2,604 outputs
Outputs of similar age
#24,165
of 329,708 outputs
Outputs of similar age from Nature Reviews Rheumatology
#8
of 49 outputs
Altmetric has tracked 25,658,541 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,604 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,708 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.