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Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells

Overview of attention for article published in BMC Research Notes, August 2010
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Title
Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells
Published in
BMC Research Notes, August 2010
DOI 10.1186/1756-0500-3-220
Pubmed ID
Authors

Xiaoying Zhang, Wei Chen, Ruth Guillermo, Gudiseva Chandrasekher, Radhey S Kaushik, Alan Young, Hesham Fahmy, Chandradhar Dwivedi

Abstract

alpha-Santalol, an active component of sandalwood oil, has shown chemopreventive effects on skin cancer in different murine models. However, effects of alpha-santalol on cell cycle have not been studied. Thus, the objective of this study was to investigate effects of alpha-santalol on cell cycle progression in both p53 mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells to elucidate the mechanism(s) of action.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 29%
Student > Bachelor 8 17%
Researcher 6 13%
Other 5 10%
Student > Postgraduate 2 4%
Other 8 17%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 38%
Biochemistry, Genetics and Molecular Biology 6 13%
Medicine and Dentistry 6 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Chemistry 4 8%
Other 4 8%
Unknown 6 13%