Title |
Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity
|
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Published in |
Malaria Journal, September 2014
|
DOI | 10.1186/1475-2875-13-359 |
Pubmed ID | |
Authors |
Sanna R Rijpma, Jeroen JMW van den Heuvel, Maarten van der Velden, Robert W Sauerwein, Frans GM Russel, Jan B Koenderink |
Abstract |
Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport proteins are particularly involved in drug deposition, as they are located at membranes of many uptake and excretory organs and at protective barriers, where they export endogenous and xenobiotic compounds, including pharmaceuticals. In this study, a panel of well-established anti-malarial drugs which may affect drug plasma concentrations was tested for interactions with human ABC transport proteins. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 2 | 4% |
Burkina Faso | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 25% |
Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 8 | 14% |
Student > Postgraduate | 4 | 7% |
Researcher | 3 | 5% |
Other | 9 | 16% |
Unknown | 10 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 21% |
Medicine and Dentistry | 10 | 18% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Agricultural and Biological Sciences | 7 | 12% |
Arts and Humanities | 4 | 7% |
Other | 7 | 12% |
Unknown | 10 | 18% |