Title |
Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway
|
---|---|
Published in |
Molecular Cancer, September 2014
|
DOI | 10.1186/1476-4598-13-214 |
Pubmed ID | |
Authors |
Julia Roediger, Wiebke Hessenkemper, Sophie Bartsch, Marina Manvelyan, Soeren S Huettner, Thomas Liehr, Mohsen Esmaeili, Susan Foller, Iver Petersen, Marc-Oliver Grimm, Aria Baniahmad |
Abstract |
Prostate cancer (PCa) is the second leading cause of cancer mortality of men in Western countries. The androgen receptor (AR) and AR-agonists (androgens) are required for the development and progression of the normal prostate as well as PCa. However, it is discussed that in addition to their tumor promoting activity, androgens may also exhibit tumor suppressive effects. A biphasic growth response to androgens a growth-promoting and -inhibition has been observed that suggests that administration of supraphysiological androgen levels mediates growth reduction in AR expressing PCa cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 2% |
Unknown | 48 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 20% |
Student > Master | 9 | 18% |
Student > Doctoral Student | 5 | 10% |
Researcher | 5 | 10% |
Student > Bachelor | 3 | 6% |
Other | 7 | 14% |
Unknown | 10 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 24% |
Agricultural and Biological Sciences | 7 | 14% |
Medicine and Dentistry | 6 | 12% |
Immunology and Microbiology | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 2 | 4% |
Unknown | 15 | 31% |