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Influência dos polimorfismos genéticos (IL10/CXCL8/CXCR2/ NFκB) na susceptibilidade das doenças reumatológicas autoimunes

Overview of attention for article published in Revista Brasileira de Reumatologia, July 2014
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Title
Influência dos polimorfismos genéticos (IL10/CXCL8/CXCR2/ NFκB) na susceptibilidade das doenças reumatológicas autoimunes
Published in
Revista Brasileira de Reumatologia, July 2014
DOI 10.1016/j.rbr.2013.10.006
Pubmed ID
Authors

Patricia Hartstein Salim, Ricardo Machado Xavier

Abstract

The autoimmune rheumatologic disorders mostly have a common genetic path to the autoimmunity. Several genes have been associated with rheumatologic disorders; therefore, we are analyzing just the ones in those containing several evidences of the existence of association with the risk or protection from autoimmune disorder. The nuclear factor kappa beta (NF-kappa B), which regulates the autoimmune and anti-inflammatory responses, is associated with systemic sclerosis (SS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), just as the CXCR2 e CXCL8 genes. On the other hand, the interleukin-10 (IL-10), which is an anti-inflammatory cytokine, is associated with almost all rheumatologic disorders. In this article, we are reviewing the potential roles of these genes in the immune system and in several rheumatologic disorders. In relation to IL-10, several studies have been carried out, but most of them are controversial - some detected the absence of association, and others found association in different genetic polymorphisms. Conversely, in relation to NF-kappa B, it was studied just in RA and SLE, and no relevant significant analyses were observed. The genetic polymorphisms of the CXCR2 gene were associated with SS, but not with RA e SLE. On the other side, the genetic polymorphisms of the CXCL8 gene are not associated with SS, but with RA.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 20%
Student > Master 1 20%
Unknown 3 60%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 20%
Immunology and Microbiology 1 20%
Chemistry 1 20%
Unknown 2 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2014.
All research outputs
#3,894,665
of 4,655,155 outputs
Outputs from Revista Brasileira de Reumatologia
#140
of 156 outputs
Outputs of similar age
#93,158
of 116,451 outputs
Outputs of similar age from Revista Brasileira de Reumatologia
#4
of 5 outputs
Altmetric has tracked 4,655,155 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 156 research outputs from this source. They receive a mean Attention Score of 1.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,451 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.